An imbalance between oxidative stress and antioxidant capacity is thought to play an important role in the pathogenesis of chronic obstructive pulmonary disease (COPD). Zinc supplementation may have favorable effects on oxidant-antioxidant balance in patients with COPD. 

cite：Kirkil G, Hamdi Muz M, Se?kin D, Sahin K, Kü?ük O. Antioxidant effect of zinc picolinate in patients with chronic obstructive pulmonary disease. Respir Med. 2008 Jun;102(6):840-4. doi: 10.1016/j.rmed.2008.01.010. Epub 2008 Mar 4. PMID: 18295467.